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This household incorporates just one protein, SET7/9, which mono-methylates histone at H3K4 ninety two KMT7 was found to methylate, in addition to histone, a variety of non-histone proteins, together with p53, DNA methyltransferase 1 (DNMT1), estrogen receptor alpha (ERα), nuclear issue kappaB (NFκB), and elements of the TATA binding protein (TBP) complex, TBP-related elements TAF10 and TAF7 93 The consensus recognition sequence in substrates for SET7-mediated lysine methylation, K/R-S/T-Ok (target lysine is bold), is also recognized by the H3K4 demethylase KDM1A/LSD1, which is able to removing the methyl mark on most of these substrates 17 , 94 Due to this fact KMT7/KDM1A has emerged as a classic model for dynamic lysine methylation of each histone and non-histone proteins. |
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The members of the SUV39 household discussed above are involved in each euchromatin and heterochromatin, but another member of the same family, G9a, is the predominant histone H3 K9 methyltransferase [lawyers in my area](http://newslabx.csie.ntu.edu.tw:3000/anhgreville61) mammalian euchromatin 14 There are two isoforms of G9a in the mouse: the brief form (GenBank accession number NP_671493 ) corresponds to human G9a and the long type ( NP_665829 ), which lacks intron one, has further Arg-Gly repeats on the amino terminus. |
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